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Amniotic Fluid

When it comes to side effects, ease of preparation, fast treatment times, and cost, PRP is above them all in orthobiologics. However, aside from PRP, there is one other alternative that is showing promise: Amniotic Fluid.

 

Due to it being a really good source of regenerative material that is not only highly proliferative, but also that produces almost no immune response, Amniotic Fluid has been a popular substance to theorize about since the late 1930’s. That is not all though, as this fluid is also high in collagen, growth factors, and hyaluronic acids. These are found in high quantities, making them a good choice for promoting regeneration.

 

This fluid is also high in stem cells that contain B7H4, a substance that promotes wound healing and even shows promise as a way of growing functional blood vessels. This was demonstrated to be true by scientists at Rice University and Texas Children’s Hospital.

 

However, we are not going to talk about that kind of Amniotic fluid. The one that we are going to talk about has been frozen, thereby killing the stem cells. This is actually a good thing, as the FDA has banned the presence of stems cells in amniotic fluids.

 

How Allografts Of Amniotic Fluids are Created

 

Allografts (Grafts taken from someone besides the person receiving it) of Amniotic Fluids are like Platelet-Rich Plasma that is already ready to be injected. This way, you and your patients receive all of the benefits associated with PRP therapy, without having to extract it yourself.

 

This amniotic fluid is taken with consent from mothers who decided to donate this fluid during a c-section. Not only were the women themselves pre-screened, but the fluid is tested again afterwards, and then prepared to be instantly used for a wide watch of medical ailments.

 

The fact that Amniotic Fluid has very little effect on one’s immune system makes it a wonderful allograft. This means that the body is far less likely to attack the donor material, making it far less likely to be rejected. Also, much like PRP, they are also known to fight inflammation, and keep microbes at bay. They are also multipotent cells, meaning they can turn into any cell they need to, making them a gold standard for regenerative medicine.

 

Since Amniotic Fluid is not taken from the person it it being used on like PRP, it misses out on a lot of those benefits. However, the large amount of elastin, fibronectin, and collagen makes it a great substance to use in wound healing and cell regeneration. It also contains a ton of growth factors, including PDGF, EGF, VEGF, and FDF to name a few.

 

Amniotic Fluid Allograft

 

It is often used to improve chronic pain conditions, as well as sports injuries, arthritis, and potentially even the symptoms of aging. It can be used by doctors along with PRP therapy to increase the effectiveness of the therapy. It can also be combined with bone marrow aspirates or hyaluronic acid.

 

The Potentials Of This

 

Many doctors may not want to spend the time and money investing in PRP therapies, so we think that Amniotic Fluid in general, could be a wonderful alternative to PRP therapy. Also, this can also be used as a stepping stone to help providers that are new to regenerative medicine to potentially get to PRP or stem cells over time.

 

We are convinced that once you get started with regenerative medicine, whether it be Amniotic Fluids, PRP therapies, or stem cell therapy, you will prefer it over other invasive procedures for sports injuries, arthritis, and other wounds. This will help save at least a few patients from having to do any unnecessary surgical procedures.

Platelet-Rich Plasma (PRP) For Osteopathic Physicians

Although they can perform surgeries, osteopathic physicians try to avoid doing so whenever possible. Because of this, PRP seems to be an excellent fit for their practice. Since Osteopathy was built on the idea of self-healing, PRP seems to be a perfect fit.

 

A little while ago, PRP research was reviewed by The Journal Of The American Osteopathic Association, and concluded that more studies and evidence would be needed to make a solid statement on it. A little while later, a case study was filed, showcasing an 18 year old high school football player who suffered from a sports injury. The case study showed that the muscle injury healed rapidly under the effect of PRP therapy. So although PRP is not constantly held up on a pedestal by the mainstream yet, does not mean that Osteopathic Physicians can’t learn a lot or benefit from the use of PRP in their practice.

 

How Osteopathic Physicians can Benefit From PRP

 

  1. It’s Holistic

 

Due to the fact that Osteopathic Physicians prefer to treat the patient, as opposed to just treating a disease or the symptoms, PRP is a great fit. It works by using the body’s own resources and mechanics and helps the body to heal itself over time. It works because, instead of simply dealing with symptoms, like many practices and conventional medicine does, it works to deal with the problem head on.

 

For instance, there are many examples of PRP therapy taking the place of surgery and medicine. Such as the cases where female patients were able to revive their sex drive, although they were initially treated for incontinence. So although PRP therapy was created and pushed by allopathic doctors at first, PRP works wonders in the field of Osteopathic medicine, and can become one of the best methods of treatment for Osteopathic physicians.

 

  1. Musculoskeletal Issues

 

In some practices, musculoskeletal pain can be something that Osteopathic Physicians deal with often. However, it is good to note that PRP is quickly becoming one of the main treatments for these kinds of issues. For instance, many researchers believe that PRP should be the main choice for people who suffer from knee meniscus.

 

In 2016, University of Missouri Doctor Patrick Smith published a FDA-sanctioned double-blind randomized placebo controlled clinical trial on PRP. These kinds of trials are considered the gold standard in research. The results of the study was that PRP provided safe and notable benefits for people who suffer from knee Osteoarthritis.

 

  1. PRP has a great deal of potential

 

The third and most important reason why all physicians, including Osteopathic Physicians, should start using PRP therapy is due to how wide its scope is. Due to the fact that PRP is simple and common, it is safe to say that if PRP can work on knee joints and tendons, that it most likely works on other tendons, joints, bones, and muscles as well. PRP will soon be a commonplace treatment when it comes to pretty much all musculoskeletal diseases.

 

This means that PRP has a near limitless potential. This is especially important for Osteopathic Physicians, as if there is a problem with the patients wrist, it could be that the main issue appears further down the arm. This is why multiple PRP injections on various areas of the arm can work to not just heal the issue, but also enhance the other traditional methods that are used. This will help restore the balance t the body, and give full functionality back to the patient.

 

American Academy of Regenerative Medicine Doctor Peter Lewis has administered over 100,000 PRP injections to over 12,000 patients. He claims that more than 80% of his patients who have gotten PRP therapy has had fantastic results. Even people who have claimed to need surgery could be benefited by the use of PRP.

 

Are They FDA Approved?

 

As of this year, PRP treatments are not yet subject to FDA approval. This is because all of the treatments are performed on the same day as the extraction, and uses only materials that are already inside the patients own body. Because of this, the PRP therapy is within the scope of the FDA Code of Federal Regulation title 21, part 1270, 1271.1. As a result, it is exempt from needing approval.

How does the U.S. FDA regulate cell therapies?

How does the U.S. FDA regulate cell therapies? (351 vs 361 Products)

In the United States, cellular therapies are regulated by the FDA’s Office of Cellular, Tissue, and Gene Therapies (OCTGT) within the FDA Center for Biologics Evaluation and Research (CBER).

According to the FDA, the Center for Biologics Evaluation and Research (CBER) regulates:

Cellular therapy products
Human gene therapy products
Certain devices related to cell and gene therapy
CBER uses both the Public Health Service Act and the Federal Food Drug and Cosmetic Act as enabling statutes for oversight.

In the U.S., human tissues intended for transplantation are regulated by the FDA as “Human cells, tissues and cellular and tissue-based products” or “HCT/Ps.” Under U.S. law, any company that engages in the collection, processing, storage, screening/testing, packaging, or distribution of HCT/Ps must register with the FDA.

351 vs. 361 Products
Currently, the FDA’s Center for Biologics Evaluation and Research (CBER) is responsible for regulating HCT/Ps and it has two different paths for cell therapies that it constructed to reflect what it considers to be “relative risk”. These pathways are commonly called “361” and “351” products.

Cell therapies can potentially be regulated under either pathway, as described below:

361 Products
361 products that meet all the criteria outlined in 21 CFR 1271.10(a) are regulated as HCT/Ps and are not required to be licensed or approved by the FDA. These products are called “361 products,” because they are regulated under Section 361 of the Public Health Service (PHS) Act.

351 Products
In contrast, if a cell therapy product does not meet all the criteria outlined in 21 CFR 1271.10(a)), then it is regulated as a “drug, device, or biological product” under the Federal Food, Drug, and Cosmetic Act (FDCA) and Section 351 of the PHS Act. These 351 products require clinical trials to demonstrate safety and efficacy in a process that is nearly identical to that what is required for pharmaceutical products to enter the marketplace.

Top 3 Reasons we offer doctors marketing services

Here at Adimarket, we sell equipment to practices that are willing and able to add PRP and stem cell therapies to their lineup. The equipment we offer is among the best, and we have helped hundreds of doctors and practices to offer PRP and stem cell therapies. However, we also provide marketing services above that as well.

 

Although it might see odd that we offer both marketing services, as well as equipment, but it is not so odd once you understand why. Simply offering services and having the equipment to do so does not in itself help patients to fully know that you are offering new services. It is best practice to get the word out to as many people in the area as possible.

 

While there are many reasons why we do this, here are the three main reasons why.

 

Regenerative Medicine Was Founded Not Too Long Ago 

Compared to many other medical practices, such as surgery and physical therapy, regenerative medicine is still fairly new. In fact, most people do not really know that PRP and stem cell therapy even exists, let alone can be used to manage chronic pain.

 

The fact that not many people even know about the existence of regenerative medicine, let alone what it can be used for, means that it would be difficult to get your patients to even understand what you are offering as a service. This can be addressed with marketing. Through marketing, a practice can not only let it become known that they are offering these new services, but also explain shortly what the service entails.

 

Marketing Is Like Dieting 

Pretty much every doctor and dietitian knows that good nutrition is vital to great health down the line. Waiting until you’re sick and deficient to discuss nutrition is not the best way to address the issue. Marketing is similar in that instance. Marketing not only can be used to keep current patients informed, but can also be used to inform new patients about what you offer. Practices that don’t market often suffer in the same way as people who don’t get good nutrition.

 

There’s a lot of competition 

Medicine has sadly become more and more like a business in the past years. This means that even doctors and practices need to have a good business sense if they are going to continue to be able to provide the type of services that patients need and desire. Not understanding business would only make any practice fail or at least prevent them from growing.

 

Because of this, private practices, as well as other medical groups are forced to compete. Marketing is a big way to make sure that you get patients instead of your competition. If you are utilizing PRP and stem cell therapies as a way to generate more income, then great! However, you will still have to market those services to get the word out, as well as compete.

 

We at Adimarket offer these services as a way to help the field of regenerative marketing succeed. We not only help your practice start to utilize regenerative medicine, but we also help you to promote your practice in the same way. This will help your patients know that you are using these methods, and what they are, so that you can get a leg up over the competition.

Stem cell therapy’s future

Stem cells from adults were found to save the lives of leukemia patients through bone marrow transplants more than 30 years ago. Since these stem cells were able to help treat leukemia and lymphoma, many scientists tested to see if this treatment can have other beneficial uses as well, such as treating other diseases and injuries. In the 80’s and 90’s, this started the Stem Cell debate, and although that has become much calmer of a debate, we are still waiting to see the boom of medical advancements promised by stem cell researchers.

 

While researchers may have over-exaggerated the exact benefits that stem cell therapy may have had, we at Adimarket knows that there are many more benefits of stem cells than we currently know. We just need to give it a little more time for researchers to understand the knicks and knacks of how stem cells interact with the human body.

 

What Are The Different Types of Stem Cells

The first while after stem cell research began, most of the time was spent learning about the two types of stem cells. These types are Adult, and Embryonic. Adult stem cells are used for bone marrow transplants and a few other treatments. Embryonic stem cells have proved to be too impractical to be useful.

 

A few decades later, in 2006, researchers in japan found a new way of using adult stem cells. They learned how to basically reprogram adult stem cells to act more like embryonic stem cells, and can become whatever cell type is needed at the time. These new cells were called Pluripotent, or iPS, stem cells.

 

While these cells were, in practice, viable, they did not come without complications. For instance, the new iPS cells became prone to mutation over time, leading to cancer in some instances.

 

Making The Research More Targeted

While the problems became a setback for some, it actually helped us to understand stem cells in the long term. Today, the focus of stem cell research is more about targeted therapies mainly used to help tissue damage, and this make sense.

 

Since cell reprogramming is no longer used as a method, stem cells taken from a tissue can only be used to create that same tissue. For instance, stem cells taken from a joint can only be used to make the tissue that the stem cells came from. This limits what stem cells can currently do at the present time. However, we believe that these limits are not permanent, and researchers will eventually find new and exciting ways to utilize stem cells.

 

Until then, Adimarket is happy to provide the equipment necessary to allow practices to utilize Platelet Rich Plasma and Stem Cell therapies. We hope that our equipment can be used to offer more treatment options for patients who are suffering from injuries and arthritis.

 

PRP and stem cell therapies seem to have a pretty bright future ahead of them. If you are a doctor or own a practice, you can be a part of this future by purchasing our equipment. If you have any questions for us, or want to know more, you can visit our website.

PRP and stem cell treatments being studied for hair loss

Hair loss is very common, with tens of millions, if not hundreds of millions of people all over the world suffering from it. Hundreds of thousands of people decide to utilize hair restoration therapy, as well as other procedures in order to try to get at least some of their former hair back. Although some are effective, most of the time, the treatments only move already existing hair from one place to another. However, with Stem Cell therapy, we try to help new hair grow by helping the follicles to regenerate.

 

Adimarket helps, alongside a few other companies, to help provide new and reliable uses for PRP and stem cell therapies. We provide the equipment and other services so that doctors and practices will be able to provide these services to their patients.

 

There’s a Lot of Promise

While the main people talking about PRP and stem cell therapies are smaller companies like us, many other people are also discussing and seeing potential in these therapies. These include doctors, and practices, such as a doctor from Miami known as Lazaro M Garcia Md. This doctor already utilized PRP and stem cell therapy for people who suffer from hair loss, and is currently conducting a study that is supported by the National Institutes of Health.

 

In order to participate in the study, patients pay a small fee, which changes based on what part of the study they are in. Afterwards, the receive 2 injections of PRP and stem cells that are made from their own body, over 3 months.

 

Dr. Garcia is utilizing the body’s own growth factors in order to increase the amount of blood and nutrients to the otherwise dead hair follicles. This makes the dead follicles more lively and allows them to create new hair growth.

 

The way to make Platelet Rich Plasma is to is to use the patients own blood, which can come from either bone marrow, or other sources of fat. They go into a centrifuge, which concentrates the composition, and then allows them to be injected into the treatment site. While it is an otherwise simple procedure, some training in still necessary to ensure that it is done safely.

 

We Provide Equipment

We at Adimarket do not perform stem cell and PRP therapies, but we do offer the equipment so that doctors and practices can do so themselves. These include amniotic tissue, stem cell and PRP kits, centrifuge devices, and many more. Practices and doctors can order directly from us.

 

It is good to note that not all PRP systems are equal. The system that we have uses the closed tabletop system that is able to process the PRP in under 10 minutes. For more information, contact us or visit our website.

 

Hair loss is a serious problem with many people suffering from it. Now, thanks for PRP and stem cell therapies, we no longer only have to rely on hair replacement surgery to help patients. PRP and stem cell therapies may be the best therapy out there for both your patients, as well as your practice.

How To Get Platelet Rich Plasma (PRP)

Platelet Rich Plasma is a very important material, as it is be vital in treating bone and joint deterioration. Many patients have tried using PRP therapy as a treatment as an alternative to surgery and other procedures that can be invasive. This therapy relies on extracting platelets and other cell types, such as growth factors, from the patients blood, and concentrating them.

 

Many conditions have been treated by using this therapy, such as knees, hips, spines, shoulders, and pretty much any part of your body that has a joint or connective tissue.

 

What The Procedure Is Like 

The procedure involves an injection of PRP at the point where treatment point. During the day, when the patient comes in, they wait while the PRP is processed. When it is done, the skin of the treatment site will be cleaned and sanitized much like a normal injection, such as a flu shot. Then, using ultrasound or fluoroscopy, the needed will be guided to the treatment area.

 

It generally takes less than 15 minutes for this procedure to take place. Then the physician or doctor in question will provide the patient with a list of things they should or should not do, such as not taking NSAIDs, such as Advil or Tylenol. If needed, other non-NSAID pain relievers may be prescribed.

 

What Should You Expect? 

PRP brings platelets and growth factors in a concentrated form to the treatment area, as a result, your body reacts in a way that ultimately increases tissue repair. This bodily process will occur for weeks, even after one application of PRP.

 

After about a month to 6 weeks, most patterns will start to feel their pain decrease, and their mobility get better. This can occur for up to half a year. While most patients are satisfied with just one treatment, many will have more than one, depending on the severity of the defect. As a result of how well this treatment works many patients are able to avoid surgery altogether with just a couple of shots.

Why do we side with stem-cell therapy?

PRP and Stem Cell Therapy still has a ways to go before it becomes mainstream medical practice. However, we at Adimarket are proud to be a part of this growing trend. We fervently believe in the future of stem cell therapies because we trust that this is an alternative to otherwise invasive and unneeded medical procedures.

 

If we listed every single scientific reason showing the benefits of stem cell therapy, we would be writing a book. In order to help keep this short, we have decided to instead make it into 3 reasons for why we side with this therapy and sell equipment for such.

 

1. It’s Been Around For Awhile

Stem cell therapy is not a new invention, nor is it an untested invention. This has been a therapy that has been going on for decades, and have been used for many procedures, such as bone marrow transplants for leukemia patients. The main issue is that stem cell therapy is just not that widely known.

 

This has been benefiting people who have suffered from leukemia, and well as other diseases like lymphoma for decades. The most common usage arising from bone marrow transplants. This is because they can be used safely and have pretty much no risk of rejection due to them being the bodies own cells. If they can be used to treat thee conditions, there is probably much more that they can be used for as well.

 

2. It’s Not Really Invasive

Invasive procedures will probably never  fully be obsolete, a good case of this would be a bone fracture, or a having to get a tooth pulled. There is nothing that can be done outside of an invasive procedure for these types of injuries. However, not all cases of invasive surgery are necessary.

 

This is why we at Adimarket love them cell therapy so much, because it is minimally invasive. Instead of needing an incision and stitches, the most that a patient will need is a needle poke to extract stem cells, and another to put them in the treatment area. This helps to not only reduce the risk of infection, but also helps prevent other complications as well, such as scarring.

 

3. It Works to Improve Healing

The last reason for us promoting stem cell therapy, is because it allows the body to heal naturally. This means that the treatment actually addresses the underlying problem, instead of just focusing on symptom management.

 

We hope that this helps patients to get better and more effective treatment, and can treat the whole issue, instead of just the symptoms of the issue. While stem cell therapy might not be the best choice for every case, it is no different than any other medical procedure. Not all treatments require medication and surgery, for instance.

 

If you are seeking out better and more efficient ways of treating injuries and various diseases, Adimarket is the place to go. We provide the latest and greatest technology and equipment in relation to PRP and stem cell therapy. These will help you to find better treatment for your patients.

 

Stem cell therapy can be highly beneficial when it comes to not only treating patients, but also to increase your revenue. Incorporating stem cell therapy may very well be the best thing that you can do for your practice.

Why Do We Side With Stem-Cell Therapy?

PRP and Stem Cell Therapy still has a ways to go before it becomes mainstream medical practice. However, we at Adimarket are proud to be a part of this growing trend. We fervently believe in the future of stem cell therapies because we trust that this is an alternative to otherwise invasive and unneeded medical procedures.

If we listed every single scientific reason showing the benefits of stem cell therapy, we would be writing a book. In order to help keep this short, we have decided to instead make it into 3 reasons for why we side with this therapy and sell equipment for such.

  1. It’s Been Around For Awhile

Stem cell therapy is not a new invention, nor is it an untested invention. This has been a therapy that has been going on for decades, and have been used for many procedures, such as bone marrow transplants for leukemia patients. The main issue is that stem cell therapy is just not that widely known.

 

This has been benefiting people who have suffered from leukemia, and well as other diseases like lymphoma for decades. The most common usage arising from bone marrow transplants. This is because they can be used safely and have pretty much no risk of rejection due to them being the bodies own cells. If they can be used to treat thee conditions, there is probably much more that they can be used for as well.

 

  1. It’s Not Really Invasive

 

Invasive procedures will probably never  fully be obsolete, a good case of this would be a bone fracture, or a having to get a tooth pulled. There is nothing that can be done outside of an invasive procedure for these types of injuries. However, not all cases of invasive surgery are necessary.

 

This is why we at Adimarket love them cell therapy so much, because it is minimally invasive. Instead of needing an incision and stitches, the most that a patient will need is a needle poke to extract stem cells, and another to put them in the treatment area. This helps to not only reduce the risk of infection, but also helps prevent other complications as well, such as scarring.

 

  1. It Works to Improve Healing

 

The last reason for us promoting stem cell therapy, is because it allows the body to heal naturally. This means that the treatment actually addresses the underlying problem, instead of just focusing on symptom management.

 

We hope that this helps patients to get better and more effective treatment, and can treat the whole issue, instead of just the symptoms of the issue. While stem cell therapy might not be the best choice for every case, it is no different than any other medical procedure. Not all treatments require medication and surgery, for instance.

 

If you are seeking out better and more efficient ways of treating injuries and various diseases, Adimarket is the place to go. We provide the latest and greatest technology and equipment in relation to PRP and stem cell therapy. These will help you to find better treatment for your patients.

 

Stem cell therapy can be highly beneficial when it comes to not only treating patients, but also to increase your revenue. Incorporating stem cell therapy may very well be the best thing that you can do for your practice.

What Are Growth Factors and Blood Platelets

We at Adimarket are specialists in stem cell and PRP (platelet rich plasma) therapies. We provide the necessary equipment and technology in order for doctors to grow their practice, so we know a fair amount about what growth factors are and what their use is in PRP therapy.

 

According to the science, blood platelets do not have a cell nucleus, and hereby do not have a typical cell structure of their own. They are derived through bone marrow an have important wound and injury healing properties. However, these platelets are rich in growth factors. In fact, they have well over 30 different growth factors in them. Let us list a couple for you.

 

Fibroblast Growth Factor (FGF) – These can have a variety of functions, but mainly play a role in embryonic development and help the wound healing process. They are useful due to their ability to create different types of tissues, which is vital in PRP therapy.

 

Platelet-Derived Growth Factor (PDGF) – This is a common growth factor that is stored in the body. It’s use is to help blood vessels grow. How they do is this is to use cells from blood vessels that exist to make new blood vessel tissue, or angiogenesis.

 

Insulin-Like Growth Factor 1 (IGF-1) – This growth factor is also doubles as a hormone. It is structured very similarly to insulin, and it’s main role is to help children grow during infancy. This is primarily why it is commonly found in breast milk.

 

Epidermal Growth Factor (EGF) – This is a growth factor that has been located all throughout the human body. It helps to stimulate cell growth, as well as create new cells. This growth factor is very useful when it comes to healing wounds and well as recovery from injuries.

 

Vascular Endothelial Growth Factor (VEGF) – VEGF is more of a protein then a factor all its own. It is used both angiogenesis, and vasculogenesis (the creation of new blood vessel tissue). If your body is injured, this growth factor will come into play and help your blood vessels recover by creating new tissue. It is also useful in creating muscle tissue, as well as creating new blood vessels to bypass ones blocked by atherosclerosis.

 

All of these five growth factors, despite acting differently from one another, all share the same kind of relation in terms of healing wounds and helping people to recover from injuries. This is the reason who platelet-rich plasma can easily work as an alternative to certain invasive surgeries. These natural growth factors help to form and create new tissue that is lost.

 

The Procedure Is Pretty Simple

 

If you are a practice looking to include stem cell and PRP therapies to your lineup, then it would be good to note that this therapy is extremely easy to learn. In fact, you can learn how to do it in just a couple of short days.

 

How does the PRP therapy work?

 

Once the patient is diagnosed, the first thing that you would want to do is draw a sample of blood. This blood will then be processed using a piece of centrifuge equipment. This will separate the platelets and plasma from the rest of the blood. After this, the platelets and plasma can then be injected into the treatment site. The most that this should take is about an hour.

 

If you want to know more about PRP therapy, as well as learn more about, or buy, the technology used to make it happen, visit us at Adimarket.

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